The Vyvanse generic name is known as Lisdexamfetamine dimesylate. It is a CNS stimulant commonly used for treating ADHD (Attention Deficit Hyperactivity Disorder). It is also used for treating BED (Binge Eating Disorder). It can be prescribed to children, adolescents, and adults. ADHD impacts a person’s ability to focus and self-control, while BED involves eating large amounts of food repeatedly even after feeling full.

As a central nervous system stimulant, Vyvanse drug classified as a Schedule II controlled substance due to its potential for misuse and dependence. It is not a narcotic but an amphetamine.

Vyvanse Mechanism of Action and Composition :

Mechanism of action Vyvanse involves the following steps:

  • Prodrug Activation: Generic Vyvanse is a pro-drug that gets activated after being metabolized into dextroamphetamine. This metabolization occurs in the gastrointestinal tract, gradually releasing the active compound.
  • Neurotransmitter Modulation: It increases the levels of norepinephrine and dopamine in the body by blocking their reuptake and promoting their release. This leads to improved focus, attention, and impulse control.
  • Inhibition of Reuptake: Dextroamphetamine also inhibits the reuptake of dopamine and norepinephrine by blocking their transporters. This leads to a higher concentration of these neurotransmitters in the synaptic cleft. Which results in enhanced communication between neurons.
  • Enhanced Brain Activity: These increased levels of dopamine and norepinephrine help to enhance brain activity, improve focus, and reduce hyperactivity and impulsive behaviors in people with ADHD. For BED, the same neurotransmitters are responsible for impulse control and behavior regulation. 

Composition:-

Vyvanse capsules come in different variants, such as 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, and 70 mg. Each capsule contains:

  • Active Ingredient: Lisdexamfetamine dimesylate
  • Inactive Ingredients: Microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and gelatin for the capsule shell.

Vyvanse Uses and Dosages:

Vyvanse dose is generally taken orally, and it is indicated for:

  • Treatment of ADHD in children aged 6 years and older and adults.
  • Treatment of moderate to severe BED in adults.

Recommended Vyvanse Dosage:-

  • ADHD: Starting from 30 mg once daily in the morning.Vyvanse max dose of 70 mg/day. The dose may be adjusted based on the clinical response.
  • BED: Starting from 30 mg once daily. Maximum dose of Vyvanse in 24 hours 70 mg/day based on individual response.

Generic Vyvanse Missed Dose/ Overdose:

If a dose is missed, take it as soon as you remember unless it is close to the next scheduled dose. Do not try to compensate for the missed dose by doubling up on doses. 

An overdose of Vyvanse may result in severe health complications, including symptoms such as restlessness, rapid heart rate, and severe anxiety. Seek immediate medical attention if any of these symptoms related to overdose are observed.

Vyvanse Side Effects In Females & Males:

Common Side Effects

Side Effects While Treating ADHD:

  • Decreased appetite
  • Vomiting
  • Diarrhea
  • Upper stomach pain
  • Dizziness
  • Trouble sleeping (insomnia)
  • Dry mouth
  • Nausea
  • irritability

Side Effects While Treating BED:

  • Constipation
  • Trouble sleeping
  • Dry mouth
  • Decreased appetite
  • Increased heart rate
  • Feeling jittery
  • Anxiety

All the mentioned side effects are often mild but should be monitored.

Serious Side Effects

Serious side effects requiring immediate medical attention include:

  • Severe allergic reactions (e.g., swelling of the face or throat)
  • Chest pain or shortness of breath
  • Uncontrolled movements or tics
  • Hallucinations or paranoia
  • Signs of cardiovascular problems (e.g., high blood pressure)
  • Mental health problems (e.g., bipolar illness, psychotic/maniac symptoms)
  • Circulation problems (Raynaud’s phenomenon)
  • Substance Abuse problems
  • Swollen lymph nodes
  • Nosebleed
  • Changes in emotions (you could feel emotions very strongly or you do not feel emotions at all)
  • Delusions (you believe things that do not make sense to others like you have special powers)
  • Slowed Growth in Children
  • Serotonin Syndrome
  • Dizziness, feeling lightheaded or fainting
  • Upper Abdominal Pain

Vyvanse Drug Interactions:

Vyvanse can interact with various medications and substances. It is advised to consult with your doctor about all other prescribed drugs that have been a part of your life, such as:

  • MAO Inhibitors: Should not be taken within 14 days due to the risk of hypertensive crisis.
  • SSR Inhibitors: medicine commonly used for anxiety and depression
  • SNR Inhibitor: medicine generally prescribed for anxiety and depression
  • Adrenergic blockers: These are inhibited by Amphetamines.
  • Tricyclic antidepressant
  • Triptan: medicine used for migraine headaches
  • Lithium: medicine for certain mental health conditions
  • Tramadol: medicine used to treat pain
  • Buspirone: medicine commonly used for anxiety and depression
  • Fentanyl: medicine used to treat severe pain
  • Tryptophan: a supplement that is used to treat depression and other conditions

Warnings and Precautions you should consider:

While using Vyvanse is very useful for the treatment of ADHD and BED, It also comes with a lot of warnings that you should consider before using it. Like, it poses a risk of misuse due to its stimulant nature and could lead to dependency as well. It is also quite risky for cardiovascular health. 

Pregnant ladies should avoid generic drugs for Vyvanse as it poses serious risk factors. Also, there are some cases of blurring of vision, symptoms of behavioral disturbances, and thought disorders in patients with pre-existing psychotic disorders. It is also found that it makes the children, and adolescents behave quite aggressively.

It is important to note all these warnings and consult with your doctor for better understanding.

Precautions On Vyvanse:

Before taking Vyvanse:

  • Inform your doctor about any history of heart problems or mental health disorders.
  • Avoid use during pregnancy unless necessary; it can affect fetal development.
  • Avoid taking it in the afternoon, it might make it harder to sleep at night.
  • Do not split, chew, or crush the capsule unless it is mentioned chewable.
  • Do not take it if not prescribed.
  • Do not share it with other people, even if they have the same conditions as you.
  • Keep it out of reach of children.
  • Store it in a safe place to protect it from theft, as it is illegal to sell or give away this medicine.
  • People older than 65 years can be at great risk for some side effects.

Storage and Disposal Of Vyvanse Tablets:

Proper storage is essential:

  • Keep it out of reach of children.
  • Store at room temperature away from moisture and heat.
  • Original Packaging: Keep Tramadol in its original container with the label intact. It helps in proper identification and dosage information.

 

Disposal Methods

Safely dispose of unused or expired Vyvanse tablet to prevent accidental exposure or misuse.

  • Mixing with an undesirable substance.
  • Sealing in a container for disposal.
  • Utilizing drug take-back programs when available.

Alternatives:

If you consider alternatives to Vyvanse for ADHD or BED management, options include:

 

Adderall (amphetamine/dextroamphetamine): A combination of different amphetamine salts, effective for ADHD.

 

Concerta (methylphenidate): A long-acting formulation of methylphenidate used for ADHD.

 

Ritalin (methylphenidate): Another form of methylphenidate, available in both immediate and extended-release formulations.

 

Dexedrine (dextroamphetamine): A single-entity amphetamine used for ADHD.

 

Strattera (atomoxetine): A non-stimulant option for ADHD that does not carry a risk of dependence.

 

Qelbree (viloxazine): A newer non-stimulant medication approved for ADHD.

 

Kapvay (clonidine) and Intuniv (guanfacine): Non-stimulant options that can help manage ADHD symptoms.

Frequently Asked Questions (FAQ)

What is the average dose of Vyvanse for adults?

The average starting dose for adults is 30 mg once daily. The effective dose usually ranges from 30 mg to 70 mg.

 

What happens when the Vyvanse dose is too low?

If the dose is too low, symptoms like difficulty focusing, increased impulsivity, and mood swings may persist. It may feel like the medication isn’t working well.

Maximum dose of Vyvanse in 24 hours?

The maximum recommended dose of Vyvanse is 70 mg per day. Always follow your doctor’s advice on dosing.

Difference between Vyvanse and Adderall?

Both medications are effective for treating ADHD but differ in their formulations and potential for misuse.

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