Medical Advice

Oxycodone And Ibuprofen: Can You Take Them Together At The Same Time?

Oxycodone is a narcotic drug that is used to relieve pain, whereas Ibuprofen is a non-steroidal drug that is used to reduce swelling and inflammation at the source of pain. Here we will discuss how these two different mechanisms of drugs, Oxycodone and Ibuprofen, work together for specific pain relief. Also, these medicines are separately effective for pain relief. Therefore, this article explains why they are combined and how to use this duo optimally.

What Are Oxycodone and Ibuprofen?

Oxycodone is an opioid analgesic pain reliever that comes under schedule II drugs. It is prescribed for treating moderate to severe pain by blocking the signals in the brain. That means oxycodone works by binding opioid receptors in the central nervous system. As a result, it reduces pain signals and slows down nerve transmission, causing relaxation. It is commonly prescribed for post-surgical pain, cancer pain, or severe injury.

Similarly, Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) also used as a pain reliever. Ibuprofen reduces pain by reducing inflammation, swelling, and stiffness. 

Now the exciting part is, if only Oxycodone comes under Schedule II drug, is it safe to take both together? Discuss below why it is prescribed together and how it is beneficial.

Can You Take Oxycodone And Ibuprofen Together?

Oxycodone And Ibuprofen follow two different mechanisms for addressing pain. Ibuprofen acts on the direct injury to reduce pain, whereas Oxycodone blocks the signals in the brain. It binds to the opioid receptors, altering the pain signal to relaxation, and Ibuprofen inhibits the production of prostaglandins, reducing inflammation. 

Therefore, some people have a common question: Can I take oxycodone and ibuprofen together? Let’s understand the mechanism of their interactions so that you can get a clear vision of this.

In the use of oxycodone and ibuprofen together, Oxycodone reduces the brain’s response to focusing on pain, and Ibuprofen works for actual healing. Therefore, this magical duo is used for fast recovery and instant pain relief. Generally, it is recommended by the doctors for Dental surgery, Orthopedic surgery, Severe sprains or fractures, Postpartum pain, Acute lower back pain, etc.

  • As we know, ibuprofen helps reduce inflammation when combined with oxycodone, resulting in faster recovery.
  • Combinably, they can relieve stronger pain than a single drug.
  • It will help to avoid the higher dose of oxycodone, which will minimize addiction risk and chances of side effects.
  • Ibuprofen is safe with lower doses of oxycodone, which helps reduce opioid-related side effects and addiction risks.

Both medicines have different mechanisms, and their interaction does not affect any people negatively. So it is safe to use, but according to the severity of the pain. It is also important to determine the right dose for each one to avoid any adverse effects.

Prescribed Combined Dose For Oxycodone Or Ibuprofen

Combunox (5 mg oxycodone / 400 mg ibuprofen) is a combined version of Oxycodone And Ibuprofen available in the market. But most of the doctors like to prescribe separate medicines taken together. They prescribe 5 mg of oxycodone in a time gap of 4-6 hours as needed. Similarly, Ibuprofen 400–800 mg should be taken 6–8 hours of time gap as needed.

As we discussed above, how much and why are they prescribed together? Now, let’s clarify to you the mechanism behind their working together to reduce pain. 

Causes Of Side Effects

As we discussed, they are effective, but if you don’t use them carefully, they may cause some minor negative effects. For example, oxycodone targets the central nervous system by binding opioid receptors. This can affect our emotions and mood swings. This can cause Drowsiness, Dizziness, or Confusion (especially in elderly patients) for a short period. If you take Oxycodone or Ibuprofen together daily, then it may also cause Constipation or stomach upset. Because Ibuprofen blocks the enzymes COX-1 and COX-2, which are involved in the production of prostaglandins, it will reduce the protective mucus lining in the stomach and can cause gastric or, in severe cases can cause stomach bleeding.

Don’t worry; proper guidance from a doctor can also avoid them. So, before you try these combo pills, consult a healthcare professional. Take the proper dose at the right time guided by him/her, and do not take an overdose for quick results.

Frequently Asked Questions On Oxycodone And Ibuprofen

1. Can I take oxycodone and ibuprofen at the same time?

Yes, you can take oxycodone and ibuprofen together for pain relief. But if you take it after the doctor’s prescription, then it will be safe for you.

2. Why are Oxycodone and Ibuprofen prescribed together?

Oxycodone and Ibuprofen help to fast recover and provide instant pain relief. Because Oxycodone works for pain signal control, and Ibuprofen reduces inflammation. Therefore, they are prescribed together for the combined result.

3. Do they interact with each other?

No, Oxycodone and Ibuprofen don’t have any negative interaction. It is safe to use for pain management and anti-inflammatory action.

4. Is it safe to take oxycodone and ibuprofen long-term?

No, doctors usually don’t recommend it for long-term use. Because it can lead to addiction or liver problems.

5. Can I drink alcohol while taking these medications?

No, drinking alcohol should be prohibited to avoid any side effects. It may cause stomach bleeding or respiratory problems.